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What happens when people take psychedelic substances over longer periods of time? We are joined by Dipl. Psych. Tobias Buchborn (research fellow) and Laura Kärtner (research intern) from the Psychedelic research group (Imperial College, London) who will tell us about the consequences of frequent psychedelics intake, including receptor regulation, tolerance, and other sequelae. The lecture is co-hosted by the CNCR ( at the Natural Science Faculty of Vrije Universiteit Amsterdam, Room WN-D107.

Tickets available online and at the door (if not sold out). The lecture is free for registered APRA members and CNCR members. It is possible to acquire membership directly on the ticket webshop page or in the link below, granting free/discounted entrance to all APRA events, and more. If you acquire APRA membership through the ticket webpage, please make sure to also fill in the form at this link

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Lecture description:
Serotonergic hallucinogens (psychedelics) such as LSD or psilocybin are generally thought to have a low addiction liability and to be rarely taken on a high-frequency basis. One reason for the apparent lack of addictive intake patterns is the rapid loss of psychedelic effects upon everyday application (called “pharmacological tolerance”), which –unlike seen with other substances of abuse– does not seem to be readily overcome by mere dose escalation. In the recent past, however, a new pattern of recreational hallucinogen intake (called “microdosing”) has gained prominence, where small subpsychedelic doses are taken on a regular (often daily or every-other-day) basis for enhancement of well-being and creativity. But what is it that science can actually tell us about the physiological and psychological consequences of such frequent and/or long-term hallucinogen consumption?
In our talk, we will give an overview of the most important findings of how body and psyche respond to repeated exposition to serotonergic hallucinogens. (1) Adaptations of psychological functioning and behaviour, receptors and genes, brain and whole-body integrity, as well as (2) mechanisms of tolerance, and (3) recent results from the Imperial Microdosing Survey will be discussed. Aim is to provide the audience with reference points for a balanced appraisal of potential benefits and/or detriments of frequent hallucinogen intake.

Speaker bio:
Tobias Buchborn studied Psychology at the OvG University, Magdeburg Germany, and within his Diploma thesis investigated the antidepressant-like properties of repeated LSD administration in an animal model of depression. His PhD project explored the behavioural and molecular biological correlates of tolerance to LSD, DMT, and DOB. In 2016, Tobias started to work as a Marie Curie Research Fellow at Imperial College London, where his research has been devoted to the haemo- and pyramidal-cellular corticodynamics of psychedelic drug action.

Suggested reading:
Buchborn et al. (2016). Tolerance to lysergic acid diethylamide (LSD): Overview, correlates, and clinical implications. In: Preedy VR (ed.), Neuropathology of Drug Addictions and Substance Misuse, Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects, 846-858. Academic Press.

Further information:,

About the organizers:

APRA is a registered nonprofit organization run by volunteer university students and researchers. Fees and donations are fully reinvested in covering organisational costs, creating new events, and sponsoring academic research projects.

LocatieVrije Universiteit Amsterdam WN-D107
AdresDe Boelelaan 1105, 1081 HV Amsterdam
Tijd13:00 - 14:30
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